LITTLE KNOWN FACTS ABOUT PKRRATING.

The activated enzyme then phosphorylates its main substrate, the translational initiation component eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved relatives of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to unique stimuli12, triggering the built-in stress respo